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LI Ming, Deputy Director and Party Secretary

Education and Career History
B.S., Huazhong Unjiversity of Science and Technology, 1998
M.S., Jilin University,1992
Ph.D., University of Wuerzburg, 1998
Postdoc., University of Illinois at Chicago, 1998-2001
Professor, Institute of Physics, CAS, 2001-present

Research Interests
Single-molecule biophysics
The past two decades have witnessed huge advances of single-molecule techniques. Currently, the bottleneck of this field is to detect motions of molecular motors with sub-nanometer precision. We aim to develop cutting-edge techniques to solve the challenges, ranging from DNA transcations to membrane-related signal transductions. The ultimate goal in the near future is to sense actions of an enzyme driven by hydrolysis of one single ATP, to detect enzyme-induced structural changes of DNA with one base resolution, and to image trans-membrane dynamics of individual proteins at plasma membranes.

Address
Institute of Physics P.O.Box 603 Beijing, 100190, China

Selected Recent Publications

  1. Meijing Li, Xian Xia, Yuanyuan Tian, Qi Jia, Xiaoyu Liu, Ying Lu, Ming Li, Xueming Li & Zhucheng Chen, Mechanism of DNA translocation underlying chromatin remodelling by Snf2, Nature, 2019, 567,409.
  2. Dong-Fei Ma, Chun-Hua Xu, Wen-Qing Hou, Chun-Yu Zhao, Jian-Bing Ma, Xing-Yuan Huang, Qi Jia, Lu Ma, Jiajie Diao, Cong Liu, Ming Li, and Ying Lu, Detecting single molecule dynamics on lipid membranes with quenchers-in-a-liposome FRET, Angew. Chem. Int. Ed. 2019, 58, 5577.
  3. Li Ma, Shuxin Hu, Xiaolong He, Na Yang, Licui Chen, Chenguang Yang, Fangfu Ye, Taotao Wei, and Ming Li, Detection of tBid Oligomerization and Membrane Permeabilization by Graphene-Based Single-Molecule Surface-Induced Fluorescence Attenuation, Nano Lett. 2019, 19, 6937.
  4. Ping Chen, Liping Dong, Mingli Hu, Yi-Zhou Wang, Xue Xiao, Zhongliang Zhao, Jie Yan, Peng-Ye Wang, Danny Reinberg, Ming Li, Wei Li and Guohong Li, Functions of FACT in Breaking the Nucleosome and Maintaining Its Integrity at the Single-Nucleosome Level, Molecular Cell, 2018, 71, 284.
  5. Wenxia Lin, Jianbing Ma, Daguan Nong, Chunhua Xu, Bo Zhang, Jinghua Li, Qi Jia, Shuoxing Dou, Fangfu Ye, Xuguang Xi, Ying Lu, and Ming Li, Helicase Stepping Investigated with One-Nucleotide Resolution Fluorescence Resonance Energy Transfer, Physical Review Letters, 2017, 119, 138102.
  6. Wei Li,Ping Chen,Juan Yu,Liping Dong,Dan Liang,Jianxun Feng,Jie Yan,Peng-Ye Wang,Qing Li,Zhiguo Zhang,Ming Li,Guohong Li,FACT Remodels the Tetranucleosomal Unit of Chromatin Fibers for Gene Transcription,Molecular Cell,2016,64(1):120~133
  7. Renwei Liu,Suna Fan,Dongdong Xiao,Jin Zhang,Mengzhou Liao,Shansheng Yu,Fanling Meng,Baoli Liu,Lin Gu,Sheng Meng,Guangyu Zhang,Weitao Zheng,Shuxin Hu, Ming Li, Free-Standing Single-Molecule Thick Crystals Consisting of Linear Long-Chain Polymers,Nano lett.,2017,17(3):1655~1659
  8. Li, Ying,Qian, Zhenyu,Ma, Li,Hu, Shuxin,Nong, Daguan,Xu, Chunhua,Ye, Fangfu,Lu, Ying,Wei, Guanghong,Li, Ming, Single-molecule visualization of dynamic transitions of pore-forming peptides among multiple transmembrane positions,Nature Communications,2016,7:12906
  9. Li, Wei ,Wang, Peng-Ye,Yan, Jie,Li, Ming, Impact of DNA Twist Accumulation on Progressive Helical Wrapping of Torsionally Constrained DNA,Physical Review Letters,2012,109(21):218102
  10. Wei li,Pengye Wang,jie yan,Ming Li, Direct Measurement of Sequential Folding Pathway and Energy Landscape of Human Telomeric G-quadruplex Structures,J. Am. Chem. Soc.,2013,135(2):6423~6426
  11. Sun B, Wei K.J., Zhang B., Zhang X.H., Dou S.X., Li M. and Xi X.G., (2008) Impediment of E. coli UvrD by DNA-destabilizing force reveals a strained-inchworm mechanism of DNA unwinding, EMBO J., 27, 3279-3287.
  12. Yuan, B., Xing, L.L., Zhang, Y.D., Lu, Y., Mai, Z.H., and Li, M. (2007). Self-assembly of highly oriented lamellar nanoparticle-phospholipid nanocomposites on solid surfaces. J. Am. Chem. Soc., 129, 11332-3.
  13. Fu, W.B., Wang, X.L., Zhang, X.H., Ran, S.Y., Yan, J., and Li, M. (2006). Compaction dynamics of single DNA molecules under tension. J. Am. Chem. Soc. 128, 15040-1.
  14. Xing, L.L., Li, D.P., Hu, S.X., Jing, H.Y., and Li, M. Electrochemical growth of highly oriented organic-inorganic superlattices using solid-supported multilamellar membranes as templates. J. Am. Chem. Soc., 2006, 128, 1749.

Tel:86-10-82649058
Email: mingli AT iphy.ac.cn