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The 20th Lecture : Quantitative Studies of Bacteria Chemotaxis Behavior



欧阳颀,1982年毕业于清华大学化学与化学工程系,1987年于法国波尔多第一大学化学系获硕士学位,1989年于法国波尔多第一大学化学系获博士学位。1998年5月至今为北京大学物理学院教授。2013年当选为中国科学院院士。现为北京大学物理学院凝聚态与应用物理研究所所长,教授。主要从事非线性物理研究工作,近15年来以非线性物理为基础开展交叉生物学研究,在非线性科学及物理生物交叉领域取得重要成就。1997年获国家自然科学基金委“杰出青年科学基金”资助,1999年入选教育部首批“长江学者”特聘教授,任国家自然科学基金委“创新研究群体”学术带头人。2006年获得北京市自然科学奖一等奖(第一完成人)、2009年获国家自然科学奖二等奖(第一完成人)。先后担任《Chinese Physics B》和《物理学报》编委、《Chinese Science Bulletin》和《科学通报》副主编等职务。


Most biological organisms have the ability to sense their chemical environment and direct their motion toward attractants and away from repellents. This chemotactic behavior has been studied intensively in recent years. Among them, bacteria E. Coli. Chemotaxis is one of the best-studied systems in biology; it serves as an ideal model system in quantitative biology. In this talk, we will report our quantitative studies in recent years on E. Coli.chemotactic behavior under different spatiotemporal varying environments using both experimental and theoretical methods. In experiments, we developed microfluidic systems to accurately control the spatiotemporal patterns of bacteria environment, and observed the behavior of bacteria in the defined environment. The data collected the experiments was used to test the dynamics model of bacteria chemotaxis mechanism. New bacteria chemotactic behaviors were observed, and the new theoretical model was proposed.


G.W. Si, T.L. Wu, Qi Ouyang, Y.H. Tu, Pathway-Based Mean-Field Model for Escherichia coli Chemotaxis, Phys. Rev. Lett. 109, 408101 (2012).

X.J Zhu, G.W. Si, N.P. Deng, Qi Ouyang, T.L Wu, Z.R. He, L.L. Jiang, C.X. Luo, and Y.H Tu, Frequency-dependent Escherichia coli chemotaxis behavior,Phys. Rev. Lett 108, (2012) 128101.

Q.X. Cai, Z.J. Li, Qi Ouyang, C.X. Luo, V. Gordon, Singly Flagellated Pseudomonas aeruginosa Chemotaxes Ef?ciently by Unbiased Motor Regulation, mBio, 7 (2) (2016) E00013-16.

Z.J. Li, Q.X. Cai, X.Q. Zhang, G.W. Si, Qi Ouyang, C.X. Luo, Y.H. Tu, Barrier crossing in Escherichia Coli chemotaxis, Phys. Rev. Lett., 118 (2017) 098101.

X.Q. Zhang, G.W. Si, Y.M. Dong, K.Y Chen, Qi Ouyang, C.X. Luo, Y.H. Tu, Escape band in Eschrichia Coli chemotaxis in opposing attractant and nutrient gradients, PNAS, (2018)

联系人:王玉鹏研究员(8264 9345)