Chemical Reaction Revisited by in situ Electron Microscopy and Field Gradient NMR
Institute for Basic Science, South Korea
I will discuss unexpected observations and new questions that arise when we apply two techniques conventionally not used for studying chemical reactions. In the first case, inspecting base-pairing of single-stranded DNA at a single-molecule level by using real-time observation electron microscopy in aqueous environment, we observe some anticipated pathways and others that are surprising. In the second case, we find from field gradient NMR measurements and single molecule fluorescence spectroscopy that chemical reaction collectively agitates its surrounding fluids suggesting broad existence of chemistry-induced motility.
Brief CV of Dr. Huan Wang:
Huan Wang got her Ph.D degree in Analytical Chemistry from the University of Arizona under supervision of Prof. Jeanne E. Pemberton (editor-in-chief Annual Review of Analytical Chemistry) in 2015, where she studied nanostructure of polymer films at interfaces under non-equilibrium flow. Thereafter, she joined the newly launched government research institution, center for soft and living matter in South Korea, and collaborated with Prof. Steve Granick (NAS member, AAAS member), where she was recently promoted as senior research fellow. She works to enable insitu liquid-cell electron microscopy for single molecule studies of biomacromolecule interactions by direct imaging to unravel hidden mechanisms with unprecedented combination of time and spatial resolution in liquids. She is also interested in understanding the collective agitation effect of chemical reaction and additionally drying-induced pattern formation with fluorescence and NMR methods.