Theory and experiments in multivalent nanoparticles for targeted drug delivery: some recent results
（Imperial College London, UK）
One of the main promises in nanomedicine is the possibility to use nanoparticles for targeted drug delivery. Among the various systems proposed to this purpose, multivalent, ligand-coated nanoparticles are one of the leading candidates. In this system, the main idea is to impart binding selectivity by coating the particles with ligands that match receptors on the target. Whereas this simple concept is quite appealing, its application is not so straightforward as it might seem to the naive eye. In this regard, theory and simulation have been recently used to identify the sweetspots, in terms of design parameters, where this system shows selective targeting, as well as potential problems, and solutions, with multivalent targeting. Even more excitingly, theory has come out with interesting predictions in order to obtain new kinds of selectivity that can only be achieved because of the peculiar properties of multivalent interactions, predictions that can now being tested experimentally. In this talk, I will present some of our recent work along these lines, showing how theory has been used to both rationalise as well as to predict the behaviour of experiments, an integrated approach that promises to accelerate the development of nanoparticles into realistic applications.
Dr. Stefano Angioletti-Uberti obtained his PhD in Materials Science at Imperial College London in 2010, working on modelling of solid-liquid interfaces in metallic alloys. After that, he moved to the University of Cambridge in the group of Prof. Daan Frenkel, shifting his research to Soft Matter. In 2013, he was awarded a prestigious Alexander von Humboldt Research Fellowship and moved to the Humboldt University of Berlin (Germany), where he continued his work on functionalized nanoparticles and surfaces with Prof. Joachim Dzubiella and Prof. Matthias Ballauff. In September 2015 he moved to Beijing University of Chemical Technology as Professor of Soft Matter, where he still holds a position as Adjunct Professor and PI in the Beijing Advanced Centre for Soft Matter Science and Engineering.
Since October 2016 he moved back to Imperial College, where he continues his research on theory and modelling of Soft Matter systems, with an emphasis on controlling materials behaviour via functionalization with ligands of biological and synthetic origin.
邀请人：Prof. Jure Dobnikar（82649513）