Mechanobiology Institute, National University of Singapore, Singapore 117411, Singapore.

Department of Physics, National University of Singapore, Singapore 117542, Singapore.

报告摘要：

Cellular mechanosensing is a fundamental aspect of biology, where cells convert mechanical stimuli into signals that regulate cellular responses to the external environment. The process of mechanosensing involves the dynamic assembly of protein complexes, which enable cells to detect and respond to tension within these complexes. To advance mechanobiological research, it is essential to probe the tension levels and durations in tension-transmission linkages of cells and connect them to the mechanical activation and downstream biochemical interactions.

In this presentation, I will discuss our recent research on the tension thresholds and duration thresholds needed for mechanosensing of cells. We utilized a combination of single-molecule mechanical assays and theoretical modeling to understand the mechanical properties of several biomolecular mechanical elements and molecular mechanical sensors. Our findings provide insights into the mechanical properties of tension-bearing protein-protein interfaces and protein domains within different tension-transmission supramolecular linkages in cells and tissues, which facilitate cellular mechanosensing. I will also demonstrate how these properties facilitate cellular mechanosensing and discuss their potentials as targets for pharmaceutical intervening. This presentation will benefit researchers and students interested in the field of mechanobiology and its potential applications in medicine.

报告人简介：

Dr. Yan Jie is a single-molecule biophysicist who earned his PhD from the University of Illinois at Chicago in 2005. He currently holds the position of Full Professor in the Department of Physics and serves as a Principal Investigator at the Mechanobiology Institute at the National University of Singapore. There, he spearheads research in single-molecule studies, focusing on the micromechanics of DNA and proteins. His primary objective is to unravel the ways in which force-bearing proteins within cells can detect and react to mechanical forces and how these proteins can be targeted pharmaceutically. Dr. Jie's contributions to the field have been widely acknowledged; he has been elected as a Fellow of the American Physical Society and a Singapore NRF Investigator. Additionally, he has published over 120 papers and secured two patents.

邀请人：李伟（82649568）